Intracoronary beta-radiation therapy for long lesions in native coronary vessels
نویسندگان
چکیده
منابع مشابه
Long-term effects of intracoronary beta-radiation in balloon- and stent-injured porcine coronary arteries.
BACKGROUND The data on the long-term safety and efficacy of intracoronary beta-radiation in animal models are limited. METHODS AND RESULTS A total of 30 coronary arteries in 15 swine were subjected to balloon or stent injury followed by beta-radiation from a centered 32P source (2000 cGy to 1 mm beyond lumen surface) or a sham radiation procedure. The animals received aspirin for 6 months and...
متن کاملIntracoronary beta-radiation exacerbates long-term neointima formation in balloon-injured pig coronary arteries.
BACKGROUND Long-term biological effects of ionizing radiation on coronary arteries remain poorly defined. We examined late arterial responses 6 months after balloon angioplasty and beta-radiation in normal pig coronary arteries. METHODS AND RESULTS Coronary arteries of 25 adult pigs were randomized to receive 20 Gy (n=8) or 30 Gy (n=9) of (186)Re beta-radiation or sham radiation (n=8) immedia...
متن کاملEffects of intracoronary beta-radiation therapy after coronary angioplasty: an intravascular ultrasound study.
BACKGROUND Endovascular radiation is emerging as a potential solution for the prevention and treatment of restenosis. Its effects on the morphology of unstented vessels cannot be determined by angiography and therefore require the use of intravascular ultrasound. METHODS AND RESULTS Through a 5F noncentered catheter for delivery of a 90Sr/Y source train, 12, 14, or 16 Gy at 2 mm was delivered...
متن کاملCorrelation between intracoronary ultrasound and fractional flow reserve in long coronary lesions. A three-dimensional intracoronary ultrasound study.
INTRODUCTION AND OBJECTIVES Intracoronary ultrasound estimation of the functional significance of intermediate angiographic lesions has mainly been based on measuring the minimal lumen area. These estimates take no account of lesion length and pay insufficient attention to long coronary lesions. METHODS We included 61 lesions with visual angiographic stenosis of 40% to 70% that required treat...
متن کاملQuantitative Analysis of Coronary Vessels with Optimized Intracoronary CT Number
BACKGROUND Variability in intracoronary computed tomography (CT) number may influence vessel quantification. We confirmed the feasibility of a novel method for measuring vessel diameter and area using coronary CT angiography (CCTA) with an optimized intracoronary CT number, 350 HU. METHODS We performed intravascular ultrasound (IVUS) imaging in 52 patients with significant stenosis detected b...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2002
ISSN: 0735-1097
DOI: 10.1016/s0735-1097(02)80244-3